Preparation of highly pure cyclo-polylactides by optimization of the copper-catalyzed azide-alkyne cycloaddition reaction

Authors

R. Liénard, T. Josse, J. De Winter, P. Dubois, P. Gerbaux, and O. Coulembier

Reference

Polimery, vol. 62, no. 4, pp. 283-290, 2017

Description

This work reports on the preparation of highly pure cyclo-polylactides (M_n ≈ 4 000 g · mol^-1) by the optimization of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction applied on α-azide-ω-alkyne linear polylactide (PLA) precursors. By adjusting parameters such as the rate of reactant addition and the catalyst loading, monocyclic PLA's with a degree of purity of 93 % are obtained in few minutes. Highly pure monocycles (purity as high as 99.9 %) are also possibly prepared in few hours.

Link

doi: dx.doi.org/10.14314/polimery.2017.283